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analyzed GLP-1 RAs efficacy in 23 patients with PWS, sixteen (70%) of which were also diagnosed with diabetes

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"These medications appear to affect brain pathways involved in reward and craving, which could help explain the lower rates of substance use disorders observed in our study." The study found that people taking GLP-1 medications had: 74% lower odds of alcohol use disorder 69% lower odds of opioid use disorder 68% lower odds of nicotine use disorder 75% lower odds of cocaine use disorder The team emphasizes that their findings do not establish cause and effect — GLP-1s do not specifically prevent patients from abusing substances